Mucosal Susceptibility to Human Immunodeficiency Virus Infection in the Proliferative and Secretory Phases of the Menstrual Cycle.

ABSTRACT: Factors underlying HIV acquisition in women remain incompletely understood. This study evaluated ex vivo mucosal HIV-1_BaL infection (ectocervix, endocervix), T cell frequencies and phenotype (ectocervix, endocervix, peripheral blood), and HIV-1_BaL-induced tissue immune responses (ectocervix) in the proliferative and secretory phases of the menstrual cycle using samples obtained from women undergoing hysterectomies. Tissue infectivity (number of productively infected explants) and infection level following 500 and/or fifty 50% tissue culture infectious dose (TCID₅₀) HIV-1_BaL challenge were similar in the proliferative and secretory phases. Although not associated with infection outcomes, higher frequencies of HIV target CD4⁺α4β7^+</

SUBMITTER: Calenda G 

PROVIDER: S-EPMC6442278 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature