Investigating Lactococcus lactis MG1363 Response to Phage p2 Infection at the Proteome Level.

ABSTRACT: Phages are viruses that specifically infect and eventually kill their bacterial hosts. Bacterial fermentation and biotechnology industries see them as enemies, however, they are also investigated as antibacterial agents for the treatment or prevention of bacterial infections in various sectors. They also play key ecological roles in all ecosystems. Despite decades of research some aspects of phage biology are still poorly understood. In this study, we used label-free quantitative proteomics to reveal the proteotypes of Lactococcus lactis MG1363 during infection by the virulent phage p2, a model for studying the biology of phages infecting Gram-positive bacteria. Our approach resulted in the high-confidence detection and quantification of 59% of the theoretical bacterial proteome, in

SUBMITTER: Lemay ML 

PROVIDER: S-EPMC6442364 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature