Ontology highlight
ABSTRACT:
SUBMITTER: Hartl D
PROVIDER: S-EPMC6442381 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Genome research 20190201 4
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is unknown to what extent the CpG dinucleotide itself actually contributes to promoter activity. To address this question, we determined the transcriptional activity of a large number of chromosomally integrated promoter constructs and monitored binding of transcription factors assumed to play a role in CpG island activity. ...[more]