Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.

ABSTRACT: Introduction: Recent nationwide surveys found that natural products, including botanical dietary supplements, are used by ∼18% of adults. In many cases, there is a paucity of toxicological data available for these substances to allow for confident evaluations of product safety. The National Toxicology Program (NTP) has received numerous nominations from the public and federal agencies to study the toxicological effects of botanical dietary supplements. The NTP sought to evaluate the utility of in vitro quantitative high-throughput screening (qHTS) assays for toxicological assessment of botanical and dietary supplements. Materials and Methods: In brief, concentration-response assessments of 90 test substances, including 13 distinct botanical species, and i

SUBMITTER: Hubbard TD 

PROVIDER: S-EPMC6442399 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature