Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice.

ABSTRACT: Copper is a critical enzyme cofactor in the body but also a potent cellular toxin when intracellularly unbound. Thus, there is a delicate balance of intracellular copper, maintained by a series of complex interactions between the metal and specific copper transport and binding proteins. The gastrointestinal (GI) tract is the primary site of copper entry into the body and there has been considerable progress in understanding the intricacies of copper metabolism in this region. The GI tract is also host to diverse bacterial populations, and their role in copper metabolism is not well understood. In this study, we compared the isotopic fractionation of copper in the GI tract of mice with intestinal microbiota significantly depleted by antibiotic treatment to that in mice not receiving such tr

SUBMITTER: Miller KA 

PROVIDER: S-EPMC6442602 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature