Biphasic mechanosensitivity of T cell receptor-mediated spreading of lymphocytes.

ABSTRACT: Mechanosensing by T cells through the T cell receptor (TCR) is at the heart of immune recognition. While the mechanobiology of the TCR at the molecular level is increasingly well documented, its link to cell-scale response is poorly understood. Here we explore T cell spreading response as a function of substrate rigidity and show that remarkably, depending on the surface receptors stimulated, the cellular response may be either biphasic or monotonous. When adhering solely via the TCR complex, T cells respond to environmental stiffness in an unusual fashion, attaining maximal spreading on an optimal substrate stiffness comparable to that of professional antigen-presenting cells. However, in the presence of additional ligands for the integrin LFA-1, this biphasic response is abrogated and th

SUBMITTER: Wahl A 

PROVIDER: S-EPMC6442626 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature