Constructing Smart Protocells with Built-In DNA Computational Core to Eliminate Exogenous Challenge.

ABSTRACT: A DNA reaction network is like a biological algorithm that can respond to "molecular input signals", such as biological molecules, while the artificial cell is like a microrobot whose function is powered by the encapsulated DNA reaction network. In this work, we describe the feasibility of using a DNA reaction network as the computational core of a protocell, which will perform an artificial immune response in a concise way to eliminate a mimicked pathogenic challenge. Such a DNA reaction network (RN)-powered protocell can realize the connection of logical computation and biological recognition due to the natural programmability and biological properties of DNA. Thus, the biological input molecules can be easily involved in the molecular computation and the computation process can be spati

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC6442726 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature