Intrathecal Therapy for Chronic Pain: A Review of Morphine and Ziconotide as Firstline Options.

ABSTRACT:

Objectives

To evaluate the evidence for morphine and ziconotide as firstline intrathecal (IT) analgesia agents for patients with chronic pain.

Methods

Medline was searched (through July 2017) for "ziconotide" or "morphine" AND "intrathecal" AND "chronic pain," with results limited to studies in human populations.

Results

The literature supports the use of morphine (based primarily on noncontrolled, prospective, and retrospective studies) and ziconotide (based on randomized controlled trials and prospective observational studies) as first-choice IT therapies. The 2016 Polyanalgesic Consensus Conference (PACC) guidelines recommended both morphine and ziconotide as firstline IT monotherapy for localized and diffuse chronic pain of cancer-related and non-cancer-related et

SUBMITTER: Deer TR 

PROVIDER: S-EPMC6442748 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature