RILA blood biomarker as a predictor of radiation-induced sarcoma in a matched cohort study.

ABSTRACT:

Purpose

Radiation-induced sarcoma (RIS) is a rare but serious event. Its occurrence has been discussed during the implementation of new radiation techniques and justified appropriate radioprotection requirements. New approaches targeting intrinsic radio-sensitivity have been described, such as radiation-induced CD8 T-lymphocyte apoptosis (RILA) able to predict late radio-induced toxicities. We studied the role of RILA as a predisposing factor for RIS as a late adverse event following radiation therapy (RT).

Patients and methods

In this prospective biological study, a total of 120 patients diagnosed with RIS were matched with 240 control patients with cancer other than sarcoma, for age, sex, primary tumor location and delay after radiation. RILA was prospectively assessed fro

SUBMITTER: Mirjolet C 

PROVIDER: S-EPMC6442988 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature