Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

ABSTRACT: The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions be

SUBMITTER: Li Y 

PROVIDER: S-EPMC6442994 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature