Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases.

ABSTRACT:

Background

Subclinical thyroid dysfunction, defined as thyroid-stimulating hormone levels outside the reference range with normal free thyroxine levels in asymptomatic patients, is associated with alterations in cardiac hemodynamics. We used Mendelian randomization to assess the role of thyroid dysfunction for cardiovascular disease (CVD).

Methods

Single-nucleotide polymorphisms associated with thyroid function were identified from a genome-wide association meta-analysis in up to 72 167 individuals. Data for genetic associations with CVD were obtained from meta-analyses of genome-wide association studies of atrial fibrillation (n=537 409 individuals), coronary artery disease (n=184 305 individuals), and ischemic stroke (n=438 847) as well as from the UK Biobank (n=367 703 in

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC6443057 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature