Ethical and social implications of using predictive modeling for Alzheimer's disease prevention: a systematic literature review protocol.

ABSTRACT: INTRODUCTION:The therapeutic paradigm in Alzheimer's disease (AD) has shifted towards secondary prevention, defined as an intervention aiming to prevent or delay disease onset in pre-symptomatic individuals at risk of developing dementia due to AD. The key feature of AD prevention is the need to treat years or even decades before the onset of cognitive, behavioural or functional decline. Prediction of AD risk and evaluation of long-term treatment outcomes in this setting requires predictive modelling and is associated with ethical concerns and social implications. The objective of this review is to identify and elucidate them, as presented in the literature. METHODS AND ANALYSIS:A systematic literature review was conducted in Medline, Embase, PsycInfo and Scopus, and was complemented with

SUBMITTER: Angehrn Z 

PROVIDER: S-EPMC6443073 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature