Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium.

ABSTRACT:

Study question

Does the uterine vasculature play a localized role in promoting stromal cell decidualization in the human endometrium?

Summary answer

Our study demonstrated that hemodynamic forces induced secretion of specific endothelial cell-derived prostanoids that enhanced endometrial perivascular decidualization via a paracrine mechanism.

What is known already

Differentiation of stromal cell fibroblasts into the specialized decidua of the placenta is a progesterone-dependent process; however, histologically, it has long been noted that the first morphological signs of decidualization appear in the perivascular stroma. These observations suggest that the human endometrial vasculature plays an active role in promoting stromal differentiation.

Study design, size,

SUBMITTER: Gnecco JS 

PROVIDER: S-EPMC6443116 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature