Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis.

ABSTRACT: BACKGROUND:Fatigue and depression are frequent and often co-occurring symptoms in multiple sclerosis (MS). Resting-state functional magnetic resonance imaging (rs-fMRI) represents a promising tool for disentangling differential associations between depression and fatigue and brain network function and connectivity. In this study we tested for associations between symptoms of fatigue and depression and DMN connectivity in patients with MS. MATERIALS AND METHODS:Seventy-four MS patients were included on average 14 months after diagnosis. They underwent MRI scanning of the brain including rs-fMRI, and symptoms of fatigue and depression were assessed with Fatigue Severity Scale (FSS) and Beck Depression Inventory II (BDI). A principal component analysis (PCA) on FSS and BDI scores was performe

SUBMITTER: Hogestol EA 

PROVIDER: S-EPMC6443168 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature