Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories.

ABSTRACT: BACKGROUND/OBJECTIVES:Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. DESIGN:Prospective population based cohort study. SETTING:The Northern Manhattan Study. PARTICIPANTS (INCLUDING THE SAMPLE SIZE):Race/ethnically diverse stroke-free individuals in northern Manhattan aged ≥40 years (n = 3298). INTERVENTION:None. MEASUREMENTS:Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was

SUBMITTER: Dhamoon MS 

PROVIDER: S-EPMC6443177 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature