Aspirin and heparin for the prevention of pre-eclampsia: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Pre-eclampsia is an important cause of death and complication for pregnant women and perinatal infant. Low-dose aspirin has been most commonly used to prevent pre-eclampsia in high-risk pregnant women. Recently, heparins have also been used alone or in combination with aspirin to prevent pre-eclampsia. However, the optimal doses and combination therapy of aspirin and heparins are not well established. Therefore, we aim to compare aspirin, heparins and their combination to prevent pre-eclampsia in a network meta-analysis.

Methods and analysis

We will search the following electronic databases from the date of database establishment to 8 January 2019: PubMed, Embase, Cochrane Library, Web of Science and ProQuest. We will also search additional studies manually. The

SUBMITTER: Huang J 

PROVIDER: S-EPMC6443197 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature