The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates <i>Tal1</i>.

ABSTRACT: Progenitors of the first hematopoietic cells in the mouse arise in the early embryo from Brachyury-positive multipotent cells in the posterior-proximal region of the epiblast, but the mechanisms that specify primitive blood cells are still largely unknown. Pluripotency factors maintain uncommitted cells of the blastocyst and embryonic stem cells in the pluripotent state. However, little is known about the role played by these factors during later development, despite being expressed in the postimplantation epiblast. Using a dual transgene system for controlled expression at postimplantation stages, we found that Nanog blocks primitive hematopoiesis in the gastrulating embryo, resulting in a loss of red blood cells and downregulation of erythropoietic genes. Accordingly, Na

SUBMITTER: Sainz de Aja J 

PROVIDER: S-EPMC6443201 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature