Reduced caloric intake during endotoxemia reduces arginine availability and metabolism.

ABSTRACT:

Background

Inadequate caloric intake increases the risk of sepsis-induced complications. Metabolic changes during sepsis indicate that the availability of the amino acid l-arginine decreases. Availability of arginine may further decrease during reduced caloric intake, which thereby limits the adaptive response of arginine-nitric oxide metabolism during sepsis.

Objective

We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability.

Design

In a randomized trial, a 7-d reduced caloric intake feed regimen (RE; n = 9) was compared with a normal control feed regimen (CE; n = 9), before 24 h of endotoxemia, as a model for sepsis. Whole-body arginine-nitric oxide metabolism and protein meta

SUBMITTER: Poeze M 

PROVIDER: S-EPMC6443292 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature