NCR^- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development.

ABSTRACT:

Background

Innate lymphoid cells (ILCs) are a newly discovered family of immune cells that have similar cytokine-secreting profiles as T helper cell subsets. Although ILCs are critical for host defense against infections and tissue homeostasis, their roles in tumor development are not well established.

Methods

We studied the function of ILC3 cells in the liver for the development of hepatocellular carcinoma (HCC) in murine HCC models using flow cytometry, adoptive transfer, and in vitro functional assays.

Findings

We found that ILC3 lacking the natural cytotoxicity-triggering receptor (NCR^-ILC3) promoted the development of HCC in response to interleukin 23 (IL-23). IL-23 serum level is elevated in HCC patients and its high expression is associated with poor

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6443584 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature