Magnetic resonance imaging of the time course of hyperpolarized ¹²⁹Xe gas exchange in the human lungs and heart.

ABSTRACT:

Purpose

To perform magnetic resonance imaging (MRI), human lung imaging, and quantification of the gas-transfer dynamics of hyperpolarized xenon-129 (HPX) from the alveoli into the blood plasma.

Materials and methods

HPX MRI with iterative decomposition of water and fat with echo asymmetry and least-square estimation (IDEAL) approach were used with multi-interleaved spiral k-space sampling to obtain HPX gas and dissolved phase images. IDEAL time-series images were then obtained from ten subjects including six normal subjects and four patients with pulmonary emphysema to test the feasibility of the proposed technique for capturing xenon-129 gas-transfer dynamics (XGTD). The dynamics of xenon gas diffusion over the entire lung was also investigated by measuring the signal inte

SUBMITTER: Doganay O 

PROVIDER: S-EPMC6443604 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature