MiR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.

ABSTRACT: Elevated prostaglandin E₂ (PGE₂) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE₂ in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE₂-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH, HPGD), in colonic tumors contributes to increased prostaglandin levels and poor patient survival. While loss of 15-PGDH can occur through transcriptional mechanisms, we demonstrate that 15-PGDH can be additionally regulated by a miRNA-mediated mechanism. We show that 15-PGDH and miR-21 are inversely correlated in CRC patients, with increased miR-21 levels associating with low 15-PGDH expression. 15-PGDH can be directly

SUBMITTER: Monteleone NJ 

PROVIDER: S-EPMC6443653 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature