Altered neural activity to monetary reward/loss processing in episodic migraine.

ABSTRACT: The dysfunctions of the mesolimbic cortical reward circuit have been proposed to contribute to migraine pain. Although supporting empirical evidence was mainly found in connection with primary rewards or in chronic migraine where the pain experience is (almost) constant. Our goal however was to investigate the neural correlates of secondary reward/loss anticipation and consumption using the monetary incentive delay task in 29 episodic migraine patients and 41 headache-free controls. Migraine patients showed decreased activation in one cluster covering the right inferior frontal gyrus during reward consumption compared to controls. We also found significant negative correlation between the time of the last migraine attack before the scan and activation of the parahippocampal gyrus and the r

SUBMITTER: Kocsel N 

PROVIDER: S-EPMC6443660 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature