Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome.

ABSTRACT: There is great interest in safe and effective alternative therapies that could benefit patients with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with a variety of physiological effects. In this context, our aim was to investigate the role of dietary Arg in experimental colitis. We used two models of colitis in C57BL/6 mice, the dextran sulfate sodium (DSS) model of injury and repair, and Citrobacter rodentium infection. Animals were given diets containing (1) no Arg (Arg⁰), 6.4 g/kg (Arg^NL), or 24.6 g/kg Arg (Arg^HIGH); or (2) the amino acids downstream of Arg: 28 g/kg L-ornithine (Orn^HIGH) or 72 g/kg L-proline (Pro^HIGH). Mice with DSS colitis receiving the Arg^HIGH diet had increa

SUBMITTER: Singh K 

PROVIDER: S-EPMC6443829 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature