A prognostic signature based on three non-coding RNAs for prediction of the overall survival of glioma patients.

ABSTRACT: Recent studies have identified certain non-coding RNAs (ncRNAs) as biomarkers of disease progression. Glioma is the most common primary intracranial cancer, with high mortality. Here, we developed a prognostic signature for prediction of overall survival (OS) of glioma patients by analyzing ncRNA expression profiles. We downloaded gene expression profiles of glioma patients along with their clinical information from the Gene Expression Omnibus and extracted ncRNA expression profiles via a microarray annotation file. Correlations between ncRNAs and glioma patients' OS were first evaluated through univariate Cox regression analysis and a permutation test, followed by random survival forest analysis for further screening of valuable ncRNA signatures. Prognostic signatures could be established

SUBMITTER: Xian J 

PROVIDER: S-EPMC6443874 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature