GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.

ABSTRACT: GPR139, a G_q-coupled receptor that is activated by the essential amino acids L-tryptophan and L-phenylalanine, is predominantly expressed in the brain and pituitary. The physiological function of GPR139 remains elusive despite the availability of pharmacological tool agonist compounds and knock-out mice. Whole tissue RNA sequencing data from human, mouse and rat tissues revealed that GPR139 and the dopamine D₂ receptor (DRD2) exhibited some similarities in their distribution patterns in the brain and pituitary gland. To determine if there was true co-expression of these two receptors, we applied double in situ hybridization in mouse tissues using the RNAscope^® technique. GPR139 and DRD2 mRNA co-expressed in a majority of same cells within part of the

SUBMITTER: Wang L 

PROVIDER: S-EPMC6443882 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature