Indole Treatment Alleviates Intestinal Tissue Damage Induced by Chicken Coccidiosis Through Activation of the Aryl Hydrocarbon Receptor.

ABSTRACT: Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities. In the present study, we examined the effects of dietary indoles, 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C), on CD4⁺T cell population and functions in chickens. Furthermore, the effects of dietary DIM treatment on chicken coccidiosis caused by an apicomplexan parasite were investigated. Dietary treatment of healthy chickens with DIM and I3C induced increased CD4⁺CD25⁺ (Treg) cells and the mRNA expression of IL-10, while decreasing number of CD4⁺IL-17A⁺ (Th17) cells and Th17-related cytokines transcripts express

SUBMITTER: Kim WH 

PROVIDER: S-EPMC6443889 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature