Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression.

ABSTRACT: The dynamic and interactive tumor microenvironment is conceived as a considerable parameter in tumor development and therapy response. Implementing this knowledge in the development of future cancer treatments could provide novel options in the combat of highly aggressive and difficult-to-treat tumors such as gliomas. One compartment of the tumor microenvironment that has gained growing interest is the immune system. As endogenous defense machinery the immune system has the capacity to fight against cancer cells. This, however, is frequently circumvented by tumor cells engaging immune-regulatory mechanisms that disable tumor-directed immune responses. Thus, in order to unlock the immune system against cancer cells, it is crucial to characterize in great detail individual tumor-associated i

SUBMITTER: Eisemann T 

PROVIDER: S-EPMC6443903 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature