Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.

ABSTRACT: Background: White matter hyperintensities of presumed vascular origin (WMH) are a common finding in elderly people and a growing social malady in the aging western societies. As a manifestation of cerebral small vessel disease, WMH are considered to be a vascular contributor to various sequelae such as cognitive decline, dementia, depression, stroke as well as gait and balance problems. While pathophysiology and therapeutical options remain unclear, large-scale studies have improved the understanding of WMH, particularly by quantitative assessment of WMH. In this review, we aimed to provide an overview of the characteristics, research subjects and segmentation techniques of these studies. Methods: We performed a systematic review according to the PRISMA statement. One thousan

SUBMITTER: Frey BM 

PROVIDER: S-EPMC6443932 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature