CpG Oligodeoxynucleotides Modulate Innate and Adaptive Functions of IgM⁺ B Cells in Rainbow Trout.

ABSTRACT: Oligodeoxynucleotides (ODN) containing unmethylated CpG motifs have been widely postulated as vaccine adjuvants both in mammals and teleost fish. However, to date, the effects that CpGs provoke on cells of the adaptive immune system remain mostly unexplored in fish. Given that rainbow trout (Oncorhynchus mykiss) IgM⁺ B cells from spleen and blood transcribe high levels of toll like receptor 9 (TLR9), the receptor responsible for CpG detection in mammals, in the current work, we have investigated the effects of CpGs on both spleen and blood IgM⁺ B cells from this species. CpGs were shown to exert strong proliferative effects on both spleen and blood IgM⁺ B cells, also increasing their survival. The fact that CpGs increase the size of IgM⁺ B

SUBMITTER: Simon R 

PROVIDER: S-EPMC6443966 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature