Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics.

ABSTRACT: Drugs of abuse, such as opiates, have been widely associated with enhancing HIV replication, accelerating disease progression and diminishing host-immune responses, thereby making it harder to effectively manage HIV infection. It is thus important to study the effects of drugs of abuse on HIV-infection and immune responses. Here, we develop mathematical models that incorporate the effects of morphine-altered antibody responses on HIV/SIV dynamics. Based on fitting the model to experimental data from simian immunodeficiency virus (SIV) infections in control and morphine-addicted macaques, we found that two of the most significant effects of virus specific antibodies are neutralizing viral particles and enhancing viral clearance. Using our model, we quantified how morphine alters virus-speci

SUBMITTER: Mutua JM 

PROVIDER: S-EPMC6443976 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature