Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.

ABSTRACT: The Foxp3 transcription factor is a crucial determinant of both regulatory T (T_REG) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires the tight regulation of Foxp3 transcriptional output, and this involves both transcriptional and post-translational regulation. Here, we show that during T cell activation, phosphorylation of Foxp3 in T_REG cells can be regulated by a TGF-β activated kinase 1 (TAK1)-Nemo-like kinase (NLK) signaling pathway. NLK interacts and phosphorylates Foxp3 in T_REG cells, resulting in the stabilization of protein levels by preventing association with the STUB1 E3-ubiquitin protein ligase. Conditional T_REG cell NLK-knockout (NLK^ΔTREG) results i

SUBMITTER: Fleskens V 

PROVIDER: S-EPMC6444001 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature