Neural function in DCC mutation carriers with and without mirror movements.

ABSTRACT:

Objective

Recently identified mutations of the axon guidance molecule receptor gene, DCC, present an opportunity to investigate, in living human brain, mechanisms affecting neural connectivity and the basis of mirror movements, involuntary contralateral responses that mirror voluntary unilateral actions. We hypothesized that haploinsufficient DCC^+/- mutation carriers with mirror movements would exhibit decreased DCC mRNA expression, a functional ipsilateral corticospinal tract, greater "mirroring" motor representations, and reduced interhemispheric inhibition. DCC^+/- mutation carriers without mirror movements might exhibit some of these features.

Methods

The participants (n = 52) included 13 DCC^+/- mutation carriers with mirror movements, 7 D

SUBMITTER: Vosberg DE 

PROVIDER: S-EPMC6444183 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature