Integrative analysis of h-prune as a potential therapeutic target for hepatocellular carcinoma.

ABSTRACT:

Background

Drosophila prune protein (h-prune) has been proved to play an essential role in regulating tumor metastasis. However, the clinical relevance of h-prune and its potential mechanism in regulating hepatocellular carcinoma (HCC) are still poorly understood.

Methods

In this study, we used tissue microarrays (TMA) containing 304 HCC tumor samples to evaluate the expression of h-prune and its correlation with prognosis. Data of RNAseq, mutation profiles, copy number variation (CNV), miRNAseq and methylation array from The Cancer Genome Atlas (TCGA) dataset were adopted to analyze the distinctive genomic patterns associated with h-prune expression.

Results

By using TMA, we found increased expression of h-prune in HCC tumor cells compared with adjacent normal tissue

SUBMITTER: Liao H 

PROVIDER: S-EPMC6444224 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature