Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population.

ABSTRACT:

Objective

SH2B1 has been identified as an interesting candidate gene for complex obesity through genome-wide association studies. Therefore, we set out to replicate the reported association with rs7498665 in our Belgian study population and to extend our study with an additional tagSNP for the SH2B1 gene region.

Methods

We genotyped both rs7498665 and rs7201929 in a population of 1,045 obese adults and 317 healthy lean individuals. Statistical analyses were performed to evaluate the role of these polymorphisms in the development of obesity.

Results

We found that the rs7498665 minor allele increases obesity risk by 26% (OR(age-sex adj) = 1.26, 95% CI 1.04-1.52, nominal p = 0.016). Logistic regression showed that the rs7201929 minor allele decreases obesity risk by 24%

SUBMITTER: Beckers S 

PROVIDER: S-EPMC6444515 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature