Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls.

ABSTRACT:

Background

Log-linear and multinomial modeling offer a flexible framework for genetic association analyses of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety of child-parent configurations. Although the calculation of statistical power or sample size is an important first step in the planning of any scientific study, there is currently a lack of software for genetic power calculations in family-based study designs. Here, we address this shortcoming through new implementations of power calculations in the R package Haplin, which is a flexible and robust software for genetic epidemiological analyses. Power calculations in Haplin can be performed analytically using the asymptotic variance-covariance structure of the parameter estimator,

SUBMITTER: Gjerdevik M 

PROVIDER: S-EPMC6444579 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature