Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.

ABSTRACT:

Background

A growing number of studies clearly demonstrate a substantial association between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD), although little is known about the shared genetics that contribute to this association.

Methods

We conducted a large-scale cross-trait genome-wide association study to investigate genetic overlap between COPD (N_case = 12,550, N_control = 46,368) from the International COPD Genetics Consortium and four primary cardiac traits: resting heart rate (RHR) (N = 458,969), high blood pressure (HBP) (N_case = 144,793, N_control = 313,761), coronary artery disease (CAD)(N_case = 60,801, N_control = 123,504), and stroke (N_case = 40,585, N_con

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC6444755 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature