Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children.

ABSTRACT:

Objective

To investigate changes in leptin and soluble leptin receptor (SLR) concentrations, and in the free leptin index (FLI) during weight loss and subsequent weight regain; and to ascertain whether these indices remain stable in the rank of the distribution in repeated measures (tracking) during perturbations of weight in obese children.

Design and measurements

In a longitudinal study, 115 obese children were examined during a 12- week weight loss programme and 28 months of follow-up. Height, weight, body composition, Tanner stages, testicular size, time of menarche, and concentrations of leptin and SLR were measured at baseline, on days 14, 33, and 82, and from months 10, 16, and 28.

Results

During weight loss, leptin decreased and the SLR increased. During weigh

SUBMITTER: Holm JC 

PROVIDER: S-EPMC6444820 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature