Changes in structural network topology correlate with severity of hallucinatory behavior in Parkinson's disease.

ABSTRACT: Inefficient integration between bottom-up visual input and higher order visual processing regions is implicated in visual hallucinations in Parkinson's disease (PD). Here, we investigated white matter contributions to this perceptual imbalance hypothesis. Twenty-nine PD patients were assessed for hallucinatory behavior. Hallucination severity was correlated to connectivity strength of the network using the network-based statistic approach. The results showed that hallucination severity was associated with reduced connectivity within a subnetwork that included the majority of the diverse club. This network showed overall greater between-module scores compared with nodes not associated with hallucination severity. Reduced between-module connectivity in the lateral occipital cortex, insula, a

SUBMITTER: Hall JM 

PROVIDER: S-EPMC6444885 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature