A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

ABSTRACT: Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of enzymes^1,2, and regulate cellular functions such as metabolism^3-5 and transcription⁶. An important 'sensor' protein that captures specific metabolic information and transforms it into an appropriate response is KEAP1, which contains reactive cysteine residues that collectively act as an electrophile sensor tuned to respond to reactive species resulting from endogenous and xenobiotic molecules. Covalent modification of KEAP1 results in reduced ubiquitination and the accumulation of NRF2^7,8, which then

SUBMITTER: Bollong MJ 

PROVIDER: S-EPMC6444936 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature