Resting Cerebral Blood Flow After Exercise Training in Mild Cognitive Impairment.

ABSTRACT:

Background

Exercise training has been associated with greater cerebral blood flow (CBF) in cognitively normal older adults (CN). Alterations in CBF, including compensatory perfusion in the prefrontal cortex, may facilitate changes to the brain's neural infrastructure.

Objective

To examine the effects of a 12-week aerobic exercise intervention on resting CBF and cognition in CN and those with mild cognitive impairment (MCI). We hypothesized individuals with MCI (versus CN) would exhibit greater whole brain CBF at baseline and that exercise would mitigate these differences. We also expected CBF changes to parallel cognitive improvements.

Methods

Before and after a 12-week exercise intervention, 18 CN and 17 MCI participants (aged 61-88) underwent aerobic fitness testing

SUBMITTER: Alfini AJ 

PROVIDER: S-EPMC6444938 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature