Differentially Expressed Genes and Molecular Pathways in an Autochthonous Mouse Prostate Cancer Model.

ABSTRACT: Prostate cancer remains a major public health problem and the second leading cause of cancer-related deaths in men in the United States. The present study aims to understand the molecular pathway(s) of prostate cancer which is essential for early detection and treatment. Dorsolateral prostate from 20 week transgenic adenocarcinoma of the mouse prostate (TRAMP) mice, which spontaneously develops prostate cancer and recapitulates human disease and age-matched non-transgenic littermates were utilized for microarray analysis. Mouse genome network and pathway analyses were mapped to the human genome using the Ingenuity Pathway Analysis (IPA) database for annotation, visualization, and integrated discovery. In total, 136 differentially expressed genes, including 32 downregulated genes and 104 up

SUBMITTER: Verma S 

PROVIDER: S-EPMC6445055 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature