Transcriptomic Diversification of Granulosa Cells during Follicular Development in Chicken.

ABSTRACT: Granulosa cells play important roles in ovarian follicular development. To better understand the molecular mechanisms involved in this physiological process in chicken, high-throughput transcriptome analyses were performed to study the expression profiles of granulosa cells harvested from 6 mm white follicles, F5 follicles and F1 follicles. The analyses elucidated a clear tendency of granulosa cells in shifting its expression profile from proliferation to differentiation during follicular development. Transcripts down-regulated during this process were mainly associated with cell division, cell cycle and DNA replication while the up-regulated transcripts were related to ribosomal function, lipid metabolism and protein synthesis. Our study for the first time provides the complete gene expre

SUBMITTER: Zhu G 

PROVIDER: S-EPMC6445143 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature