Cycloserine for treatment of multidrug-resistant tuberculosis: a retrospective cohort study in China.

ABSTRACT:

Purpose

Cycloserine has been used in multidrug-resistant tuberculosis (MDR-TB) treatment since the 1950s. We evaluated the efficacy and safety of cycloserine and sought to clarify the role of cycloserine for treatment of simple MDR-TB, pre-extensively drug-resistant tuberculosis (pre-XDR-TB), and extensively drug-resistant tuberculosis (XDR-TB).

Materials and methods

A retrospective observational study was performed in Zhejiang Province, China. We enrolled 144 cycloserine-treated and 181 cycloserine-nontreated patients consecutively and determined the treatment outcome as the primary outcome. The proportion of patients with sputum culture conversion and the frequency of adverse drug reactions were also assessed.

Results

One-hundred (69.4%) out of 144 patients in the c

SUBMITTER: Li Y 

PROVIDER: S-EPMC6445236 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature