Characterisation of peripheral blood mononuclear cell populations in periparturient dairy cows that develop metritis.

ABSTRACT: Bacterial contamination of the uterus following calving is ubiquitous in the dairy cow, 40% of cows develop postpartum uterine infection, including metritis. While predisposing factors like twinning and dystocia are associated with metritis, it is unclear why some cows remain healthy following calving and others develop uterine infection, negatively impacting animal health, milk production and economic return. Here, we profiled peripheral blood mononuclear cells of cows before calving and during postpartum metritis. We hypothesized that peripheral blood mononuclear cell function and proportions would be altered during the prepartum period in cows that develop postpartum metritis. Using flow cytometry we observed reduced proportions of peripheral CD3⁺/CD4⁺, CD4^+</

SUBMITTER: Bromfield JJ 

PROVIDER: S-EPMC6445263 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature