Folate/homocysteine metabolism and lung cancer risk among smokers.

ABSTRACT:

Background

Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis.

Objectives

The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers.

Study design

The study included 132 lung cancer patients and 396 controls from northern Poland, matched by sex, age and smoking status. The median cigarette pack-years of smoking among both cases and controls was 30.0. Serum, red blood cell (RBC) folates and serum homocysteine concentrations were measured. The genotypes in selected polymorphic sites of the MTHFR, CBS, SHMT1, MTHFD1, MTRR, MTR, TYMS DHFR, TCN2, and SLC19A1 gen

SUBMITTER: Stanislawska-Sachadyn A 

PROVIDER: S-EPMC6445430 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature