Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease.

ABSTRACT: OBJECTIVES:Mucosal healing (MH) is the goal of the "treat to target" strategy in Crohn's disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD. METHODS:This was a retrospective case-control study of 319 consecutive CD patients. The primary outcome was disabling disease occurrence (defined as surgery, hospitalizations, steroid dependency, or disease complications). The secondary endpoint was disabling disease recurrence. The Kaplan-Meier method and Cox proportional hazards model were used to calculate cumulative rates and for multivariate analysis, respectively. RESULTS:Of 319 C

SUBMITTER: Huang S 

PROVIDER: S-EPMC6445605 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature