Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients.

ABSTRACT:

Background

For the growing numbers of older transplant patients, increased incidence of infection and death compared with younger patients may limit the many benefits provided by transplantation. However, little is known about age-associated immune dysfunction in the older transplant recipient.

Methods

A cohort of 60 kidney transplant recipients, 23 older (≥ 60y) and 37 younger (30-59y), matched on antithymocyte induction and donor type (living vs deceased) was evaluated. Gene expression in peripheral blood mononuclear cells 3 months after kidney transplantation was analyzed to compare differences between older and younger patients.

Results

Proinflammatory genes were upregulated in older kidney transplant patients, including cytokines IL1-β and IL-6. Downregulated gen

SUBMITTER: Schaenman JM 

PROVIDER: S-EPMC6445656 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature