Meta-Analytic Methodology for Basic Research: A Practical Guide.

ABSTRACT: Basic life science literature is rich with information, however methodically quantitative attempts to organize this information are rare. Unlike clinical research, where consolidation efforts are facilitated by systematic review and meta-analysis, the basic sciences seldom use such rigorous quantitative methods. The goal of this study is to present a brief theoretical foundation, computational resources and workflow outline along with a working example for performing systematic or rapid reviews of basic research followed by meta-analysis. Conventional meta-analytic techniques are extended to accommodate methods and practices found in basic research. Emphasis is placed on handling heterogeneity that is inherently prevalent in studies that use diverse experimental designs and models. We intr

SUBMITTER: Mikolajewicz N 

PROVIDER: S-EPMC6445886 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature