Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector.

ABSTRACT: Despite the increasing number of studies concerning insect immunity, Lutzomyia longipalpis immune responses in the presence of Leishmania infantum chagasi infection has not been widely investigated. The few available studies analyzed the role of the Toll and IMD pathways involved in response against Leishmania and microbial infections. Nevertheless, effector molecules responsible for controlling sand fly infections have not been identified. In the present study we investigated the role a signal transduction pathway, the Transforming Growth Factor-beta (TGF-β) pathway, on the interrelation between L. longipalpis and L. i. chagasi. We identified an L. longipalpis homolog belonging to the multifunctional cytokine TGF-β gene family (LlTGF-β), wh

SUBMITTER: Di-Blasi T 

PROVIDER: S-EPMC6445956 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature