Consequent stages of developing a multi-compartmental mechanistic model for chronically inhaled nanoparticles pulmonary retention.

ABSTRACT: The paper retraces the development of a mechanistic multicompartmental system model describing particle retention in lungs under chronic inhalation exposures. This model was first developed and experimentally tested for various conditions of exposure to polydisperse dusts of SiO₂ or TiO₂. Later on it was successfully used as a basis for analyzing patterns in the retention of nanoparticles having different chemical compositions (Fe₂O₃, SiO₂, NiO). This is the first publication presenting the outcomes of modeling lung retention of nickel oxide nano-aerosols under chronic inhalation exposure. The most significant adaptation of the above-mentioned model to the conditions of exposure to metal-oxide nanoparticles is associated with the need

SUBMITTER: Katsnelson BA 

PROVIDER: S-EPMC6446054 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature